FGF Signaling Pathway in the Developing Chick Lung: Expression and Inhibition Studies
2011
FGF Signaling in Chick Lung Development
publication
Evidence: moderate
Author Information
Author(s): Moura Rute S., Coutinho-Borges José P., Pacheco Ana P. da, Mota Paulo O., Correia-Pinto Jorge
Primary Institution: University of Minho, Braga, Portugal
Hypothesis
FGF signaling is essential for proper lung development in chicks.
Conclusion
FGFRs are crucial for the interactions that determine lung branching and growth in chick embryos.
Supporting Evidence
- FGF signaling is essential for lung morphogenesis.
- FGFR inhibition led to abnormal lung growth and reduced mesenchymal tissue.
- FGF10 is crucial for the directional outgrowth of lung buds.
Takeaway
FGF proteins help the lungs grow properly in chicks, and blocking them causes problems with lung development.
Methodology
In situ hybridization and in vitro FGFR inhibition studies were performed on chick lung explants.
Limitations
The study primarily focuses on the chick model, which may not fully represent mammalian lung development.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website