Antifungal Effects of New Butyltin Compounds
Author Information
Author(s): A. Smicka, V. Buchta, K. Handlir
Primary Institution: Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice
Hypothesis
The new N-substituted butyltin compounds will exhibit antifungal activity against human pathogenic fungi.
Conclusion
The newly synthesized butyltin compounds showed good antifungal effects comparable to commonly used antifungal drugs like ketoconazole.
Supporting Evidence
- The new butyltin compounds were effective against various strains of fungi.
- The antifungal activity of the compounds was comparable to that of ketoconazole.
- Tributyltin compounds showed higher antifungal effects than dibutyltin analogues.
- The study suggests that the lipophilic character of the compounds aids their antifungal activity.
Takeaway
Scientists made new chemicals that can help fight off bad fungi that make people sick, and they work as well as some medicines doctors use.
Methodology
The compounds were synthesized by reacting tri- or dibutyltin chloride with N-substituted 2-aminoethanethiolates in benzene under anaerobic conditions, followed by in vitro antifungal testing.
Limitations
The low solubility of these compounds in water limits further research.
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