SIRT1 Genetic Variants and Lifestyle Intervention Response
Author Information
Author(s): Weyrich Peter, Machicao Fausto, Reinhardt Julia, Machann Jürgen, Schick Fritz, Tschritter Otto, Stefan Norbert, Fritsche Andreas, Häring Hans-Ulrich
Primary Institution: University of Tübingen, Germany
Hypothesis
SIRT1 genetic variants influence the metabolic response to a controlled lifestyle intervention in Caucasians at risk for type 2 diabetes.
Conclusion
SIRT1 genetic variants may affect individual susceptibility to caloric restriction and increased physical activity.
Supporting Evidence
- Minor allele carriers of rs12413112 had a significantly lower basal energy expenditure.
- These carriers showed resistance to lifestyle-induced improvement of fasting plasma glucose.
- They also had less increase in insulin sensitivity compared to major allele carriers.
- The decline in liver fat was significantly less in minor allele carriers.
Takeaway
Some people have genes that make it harder for them to lose weight and improve their health when they change their diet and exercise.
Methodology
The study involved genotyping SIRT1 SNPs in 1013 Caucasian participants and analyzing their metabolic responses to a 9-month lifestyle intervention.
Potential Biases
Potential biases may arise from the self-reported nature of lifestyle changes and the specific population studied.
Limitations
The study sample size was relatively small, which may limit the generalizability of the findings.
Participant Demographics
The study included 196 non-diabetic Caucasians, with an average age of 45.8 years, consisting of 118 females and 78 males.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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