Molecular determinants of prognosis in oesophageal cancer patients treated with chemoradiation
2008
Molecular determinants of prognosis in oesophageal cancer patients treated with chemoradiation
publication
Author Information
Author(s): Ajani J A
Primary Institution: University of Texas MD Anderson Cancer Center
Hypothesis
The expression of Gli-1 in residual squamous cell carcinoma can predict the prognosis of oesophageal cancer patients treated with preoperative chemoradiation.
Conclusion
The expression of Gli-1 correlates with poor prognosis in oesophageal cancer patients treated with chemoradiation.
Supporting Evidence
- The expression of Gli-1 correlated with poor prognosis.
- Residual cancer correlates with metastatic potential.
- Previous studies documented the expression and kinetics of Gli-1 in cancer models.
Takeaway
If doctors check how much Gli-1 is in the cancer left after treatment, they can guess how well the patient will do.
Limitations
The authors did not report a multivariate analysis.
Digital Object Identifier (DOI)
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