Telomerase Repressor Gene on Chromosome 10p15.1
Author Information
Author(s): Miura N, Onuki N, Rathi A, Virmani A, Nakamoto S, Kishimoto Y, Murawaki Y, Kawasaki H, Hasegawa J, Oshimura M, Travis W D, Gazdar A F
Primary Institution: Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Hypothesis
Cancer cells acquire immortality by activation of telomerase through the loss of a repressor gene.
Conclusion
The study suggests that a gene involved in the repression of telomerase is located on chromosome 10p15.1.
Supporting Evidence
- The study correlated hTR expression with allelic loss in pulmonary carcinoid tumors.
- Loss of polymorphic markers on 10p15.1 was highly correlated with hTR expression.
- 10p15.1 showed a stronger correlation with telomerase expression than the predicted region on 3p.
Takeaway
Some cells can live forever because they turn on a special tool called telomerase, and this study found a gene that helps turn it off.
Methodology
The study used microcell-mediated chromosome transfer, radiated microcell fusion, fluorescent in situ hybridization, and STS analysis.
Digital Object Identifier (DOI)
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