Carnosine Supplementation and Musculoskeletal Health in Adults with Prediabetes and Type 2 Diabetes
Author Information
Author(s): Saadati Saeede, Jansons Paul, Scott David, de Courten Maximilian, Mousa Aya, Feehan Jack, Mesinovic Jakub, de Courten Barbora, Szewczyk-Golec Karolina
Primary Institution: Monash University
Hypothesis
Does carnosine supplementation improve musculoskeletal health in adults with prediabetes and type 2 diabetes?
Conclusion
Carnosine supplementation does not improve muscle strength, body composition, or bone health in adults with prediabetes and type 2 diabetes.
Supporting Evidence
- Carnosine supplementation had no effect on muscle strength or body composition.
- Participants were aged 53 years on average with a mean BMI of 29.3 kg/m2.
- Forty-three participants completed the study, with no reported adverse events.
Takeaway
This study tested if taking carnosine could help people with prediabetes and diabetes feel stronger and healthier, but it didn't work.
Methodology
A randomized, double-blind clinical trial with 49 participants receiving either 2 g/day carnosine or placebo for 14 weeks.
Potential Biases
Potential bias due to self-reported adherence to supplementation.
Limitations
The study had a small sample size and may be underpowered to detect differences in musculoskeletal outcomes.
Participant Demographics
30 males and 13 females, aged 53 years on average, with a mean BMI of 29.3 kg/m2.
Digital Object Identifier (DOI)
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