Neuroimaging Findings of Psychosis in Alzheimer's Disease
Author Information
Author(s): Fardin Nabizadeh, Shadi Sheykhlou, Sara Mahmoodi, Elham Khalili, Rasa Zafari, Helia Hosseini
Primary Institution: Iran University of Medical Sciences
Hypothesis
We aimed to systematically review neuroimaging findings of delusions and hallucinations in AD patients to describe the most prominent neuroimaging features.
Conclusion
The results of our review provided evidence about the neuroimaging alterations in AD patients suffering from psychosis, hallucinations, and delusions using different imaging methods.
Supporting Evidence
- AD patients with psychosis, hallucinations, or delusions have significant differences in the volume and perfusion levels of various brain regions.
- Different EEG waves were observed in AD patients with psychosis compared to those without.
- Neuroimaging findings showed significant changes in the volume and perfusion levels of broad brain areas in AD patients.
Takeaway
This study looked at brain scans of Alzheimer's patients to see how hallucinations and delusions affect their brains, finding significant changes in brain areas.
Methodology
A systematic review of 34 studies that reported neuroimaging features of AD patients with delusion, hallucination, or psychosis.
Limitations
Most included studies lack longitudinal evaluation, and there was no assessment of sex differences or adjustments for medications used by patients.
Participant Demographics
The total number of AD patients was 2241 with mean age ranging between 60 and 82.
Digital Object Identifier (DOI)
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