Analogues of LHRH versus orchidectomy: comparison of economic costs for castration in advanced prostate cancer
1992

Cost Comparison of LHRH Analogues and Orchidectomy for Prostate Cancer

Sample size: 2061 publication Evidence: moderate

Author Information

Author(s): L.E. Rutqvist, N. Wilking

Primary Institution: Radiumhemmet, Karolinska Hospital

Hypothesis

Is the cost of LHRH analogues lower than that of surgical orchidectomy for treating advanced prostate cancer?

Conclusion

Initial treatment with LHRH analogues followed by deferred orchidectomy is more cost-effective than immediate orchidectomy.

Supporting Evidence

  • The average cost for orchidectomy was estimated at ?2,580, which is 7-31% less than for LHRH analogue treatment.
  • Initial LHRH analogue treatment followed by deferred orchidectomy could reduce costs by about 26%.
  • 85% of patients could avoid surgery with the combined treatment approach.

Takeaway

This study looked at how much it costs to treat prostate cancer with two methods: surgery and medication. It found that using medication first can save money.

Methodology

Cost estimates were based on hospital stay data and treatment times from clinical trials.

Potential Biases

Potential underestimation of costs due to reliance on average daily costs and hospital stay durations.

Limitations

The study did not include costs for clinical follow-up and diagnostic examinations, which may affect the overall cost comparison.

Participant Demographics

Most patients were elderly, with an average age of 74 years.

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