Biochemical Mechanisms and Rehabilitation Strategies in Osteoporosis-Related Pain
Author Information
Author(s): Iaconisi Giorgia Natalia, Mancini Rachele, Ricci Vincenzo, Donati Danilo, Sconza Cristiano, Marvulli Riccardo, Ranieri Maurizio, Megna Marisa, Varrassi Giustino, Della Tommasa Simone, Bernetti Andrea, Capobianco Loredana, Farì Giacomo
Primary Institution: University of Salento
Hypothesis
Understanding the biochemical and neurophysiological mechanisms behind osteoporosis-related pain is crucial for developing new rehabilitative and therapeutic approaches.
Conclusion
This review highlights advancements in understanding osteoporotic pain mechanisms and identifies promising treatments.
Supporting Evidence
- Osteoporosis causes progressive bone loss due to disruptions in biochemical processes and muscle–bone interactions.
- Effective pain management strategies include physical therapy, exercise, yoga, Pilates, and cognitive behavioral therapy.
- Pharmacological options like NSAIDs and new agents can help reduce pain when included in rehabilitation projects.
Takeaway
Osteoporosis can cause pain because it weakens bones, and there are new ways to help manage that pain through exercise and medicine.
Methodology
A systematic review including studies published from 2018 to 2024 using PubMed, Scopus, clinicaltrials.gov, and Cochrane Library.
Potential Biases
Some studies exhibited high risk of bias in specific domains.
Limitations
Variability in methodological quality of included studies and potential exclusion of relevant studies due to full text availability filter.
Participant Demographics
The review included studies with participants of various ages and genders, particularly focusing on postmenopausal women.
Digital Object Identifier (DOI)
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