Pleth Variability Index Predicts Fluid Responsiveness in ICU Patients
Author Information
Author(s): Nanadoumgar H, Loupec TL, Frasca DF, Petitpas FP, Laksiri LL, Baudouin DB, Mimoz OM
Primary Institution: CHU Poitiers, France
Hypothesis
Can the Pleth Variability Index (PVI) predict fluid responsiveness in mechanically ventilated patients with circulatory insufficiency?
Conclusion
The Pleth Variability Index can non-invasively predict fluid responsiveness in ICU patients on mechanical ventilation.
Supporting Evidence
- Twenty-one patients were responders and 19 were non-responders.
- Median PVI values were significantly higher in responders than in non-responders.
- A PVI threshold value of 17% allowed discrimination between responders and non-responders with high sensitivity and specificity.
- PVI at baseline correlated with percentage changes in cardiac output induced by fluid challenge.
Takeaway
Doctors can use a special number called the Pleth Variability Index to see if patients need more fluids to help their hearts work better.
Methodology
A prospective study in a surgical ICU with 40 mechanically ventilated patients, measuring PVI and ΔPP before and after a fluid challenge.
Limitations
Exclusion criteria included various conditions that may affect fluid responsiveness, limiting generalizability.
Participant Demographics
Mechanically ventilated patients with circulatory insufficiency.
Statistical Information
P-Value
<0.0001
Confidence Interval
95% CI = 74 to 100%
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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