Prevalence of HHV-8, CMV, and EBV in Ghana
Author Information
Author(s): Adjei Andrew A, Armah Henry B, Gbagbo Foster, Boamah Isaac, Adu-Gyamfi Clement, Asare Isaac
Primary Institution: University of Ghana Medical School
Hypothesis
What is the seroprevalence of HHV-8, CMV, and EBV among HIV-seronegative and HIV-AIDS patients in Ghana?
Conclusion
HHV-8, CMV, and EBV infections are hyperendemic in both HIV-seronegative and HIV-seropositive Ghanaians, suggesting primarily a horizontal route of transmission.
Supporting Evidence
- 78.6% of HIV-seronegative blood donors were male.
- 65.6% of HIV-AIDS patients had HHV-8.
- EBV seroprevalence was 87.2% among HIV-AIDS patients.
Takeaway
This study found that many people in Ghana have certain viruses that can cause serious diseases, and these viruses spread mainly through close contact rather than sex.
Methodology
Serum samples from 3275 HIV-seronegative healthy blood donors and 250 HIV-AIDS patients were tested for antibodies using IgG ELISA assays.
Limitations
The smaller number of HIV-AIDS patients compared to HIV-seronegative healthy blood donors may limit the findings.
Participant Demographics
3275 HIV-seronegative healthy blood donors (78.6% male, 21.4% female) and 250 HIV-AIDS patients (56% male, 44% female).
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI of 237–340 cells per microliter for CD4 counts in HIV-AIDS patients.
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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