Prognostic significance of bcl-2 expression in leiomyosarcoma of the uterus
1999
Bcl-2 Expression and Prognosis in Uterine Leiomyosarcoma
Sample size: 21
publication
Evidence: moderate
Author Information
Author(s): Zhai Y-L, Nikaido T, Toki T, Shiozawa A, Orii A, Fujii S
Primary Institution: Shinshu University School of Medicine
Hypothesis
Does bcl-2 expression influence prognosis in patients with uterine leiomyosarcomas?
Conclusion
Bcl-2 expression may correlate with a favorable prognosis in patients with uterine leiomyosarcoma.
Supporting Evidence
- Bcl-2 protein was expressed in nearly all benign smooth muscle tumors but in only 57% of leiomyosarcomas.
- 76% of leiomyosarcomas were positive for p53 protein.
- A significant positive correlation was observed between p53 mutation and p53 expression.
- Univariate survival analysis revealed that bcl-2 expression and clinical stage showed a significant correlation with prognosis.
- Positive bcl-2 expression and stage 1 disease were independent predictors of a favorable prognosis.
Takeaway
This study found that a protein called bcl-2 is often present in certain tumors and might help predict how well patients with a specific type of cancer will do.
Methodology
The study examined bcl-2 and p53 expression and mutation in human uterine smooth muscle tumors to assess their influence on prognosis.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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