YKL-40 Levels and Albuminuria in Type 2 Diabetes
Author Information
Author(s): Røndbjerg Anne K, Omerovic Emina, Vestergaard Henrik
Primary Institution: Copenhagen University Hospital Herlev, Denmark
Hypothesis
YKL-40 levels are associated with increasing levels of albuminuria in patients with type 2 diabetes.
Conclusion
YKL-40 levels are elevated in patients with type 2 diabetes and are independently associated with increasing levels of albuminuria.
Supporting Evidence
- YKL-40 levels were significantly higher in patients with normoalbuminuria and microalbuminuria compared to healthy controls.
- YKL-40 levels correlated with urinary albumin/creatinine ratio in the total group of participants.
- After adjusting for covariates, albuminuria was significantly associated with YKL-40 levels.
Takeaway
This study found that a protein called YKL-40 is higher in people with type 2 diabetes who have more protein in their urine, which can be a sign of kidney problems.
Methodology
The study examined 105 patients with type 2 diabetes and measured serum YKL-40 levels and urinary albumin/creatinine ratios.
Limitations
The study is cross-sectional, and long-term studies are needed to clarify the role of YKL-40 in predicting vascular complications.
Participant Demographics
Patients included 49 with normoalbuminuria, 35 with microalbuminuria, and 21 with macroalbuminuria, matched for age and gender.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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