The Impact of Age and Sex on Chronic Leukaemias
Author Information
Author(s): B. Jaksic, B. Vitale, E. Hauptmann, A. Planinc-Peraica, S. Ostojic, R. Kusec
Primary Institution: Department of Medicine, 'Dr 0. Novosel', Medical School, University of Zagreb and Institute 'Rudjer Boskovic', Zagreb, Yugoslavia.
Hypothesis
How do age and sex influence the prognosis of chronic leukaemias?
Conclusion
Age is a significant independent prognostic factor in chronic lymphocytic leukaemia (CLL) but not in chronic myeloid leukaemia (CML).
Supporting Evidence
- Survival in CML was not related to age or sex.
- CLL patients had an expected median survival that decreased with age.
- Relative survival rates were 0.40 for CLL and 0.13 for CML patients.
Takeaway
Older people with chronic lymphocytic leukaemia tend to live shorter lives than younger people, but age doesn't affect survival in chronic myeloid leukaemia.
Methodology
The study evaluated survival in 117 CML and 256 CLL patients, analyzing the impact of age and sex on prognosis.
Limitations
The study was conducted on patients from a single institution and may not be generalizable.
Participant Demographics
The median age of CML patients was 44 years, and 62 years for CLL patients; 52% of CML patients and 65% of CLL patients were male.
Statistical Information
P-Value
p<0.0005
Statistical Significance
p<0.0005
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