The association between childhood adversity and hippocampal volumes is moderated by romantic relationship experiences
2025

Childhood Adversity and Hippocampal Volumes: The Role of Romantic Relationships

Sample size: 196 publication 10 minutes Evidence: moderate

Author Information

Author(s): Acosta H., Jansen A., Kircher T.

Primary Institution: Philipps University Marburg

Hypothesis

A higher level of childhood maltreatment is associated with smaller hippocampal volumes in individuals that have experienced a romantic relationship breakup compared to those without a breakup.

Conclusion

The study found that childhood maltreatment is linked to smaller hippocampal volumes, particularly in individuals who have experienced a romantic relationship breakup.

Supporting Evidence

  • Participants with a breakup showed smaller hippocampal volumes associated with higher childhood trauma scores.
  • Those without a breakup had a positive association between childhood maltreatment and left hippocampal volumes.
  • Childhood maltreatment was not linked to hippocampal volumes in the absence of relationship breakups.

Takeaway

Kids who go through tough times can have smaller brain areas when they grow up, especially if they also have a breakup in a romantic relationship.

Methodology

The study used MRI to measure hippocampal volumes in young adults and assessed childhood maltreatment and relationship breakups through questionnaires.

Potential Biases

Potential underreporting of childhood maltreatment could bias results.

Limitations

The study relied on retrospective self-reports of childhood maltreatment and relationship breakups, which may be subject to bias.

Participant Demographics

Participants were 196 healthy young adults, mean age 24.0 years, 50% female, with 20.6% living with a partner.

Statistical Information

P-Value

p=0.005 for left hippocampus, p=0.031 for right hippocampus

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1111/ejn.16593

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