Gene Expression Changes in Breast Tumors After Chemotherapy
Author Information
Author(s): E L Korn, L M McShane, J F Troendle, A Rosenwald, R Simon
Primary Institution: National Cancer Institute
Hypothesis
Can we identify genes that are expressed differently in breast tumors before and after chemotherapy?
Conclusion
The study identified 17 genes that are more expressed after chemotherapy than before, which were not reported in the original analysis.
Supporting Evidence
- The study found 17 genes that were more expressed after chemotherapy.
- Cluster analysis was shown to be inappropriate for this type of analysis.
- The statistical method used controlled for multiple comparisons.
Takeaway
Researchers looked at breast cancer samples before and after treatment and found some genes that changed a lot after chemotherapy.
Methodology
The study used a paired t-test with a step-down permutation approach to analyze gene expression data from paired tumor specimens.
Potential Biases
The study does not mention specific risks of bias.
Limitations
The quality of the data on the website may affect the ability to detect interesting findings.
Participant Demographics
The study involved 20 individuals with breast tumors who underwent chemotherapy.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website