c-Jun N-terminal kinase (JNK) cooperates with Gsk3β to regulate Dishevelled-mediated microtubule stability
2007
JNK and Gsk3β in Microtubule Stability Regulation
publication
Evidence: moderate
Author Information
Author(s): Lorenza Ciani, Patricia C. Salinas
Primary Institution: University College London
Hypothesis
Does the Wnt-Dvl signaling pathway regulate microtubule stability through JNK and Gsk3β?
Conclusion
The study demonstrates that Wnt-Dvl signaling activates both JNK and inhibits Gsk3β to enhance microtubule stability.
Supporting Evidence
- Wnt signaling increases microtubule stability through JNK activation.
- Inhibition of Gsk3β is necessary for the stabilization of microtubules by Dvl.
- Small Rho GTPases are not required for Dvl-mediated microtubule stability.
- JNK activation directly enhances microtubule stability in neurons.
Takeaway
This study found that a signaling pathway called Wnt can help keep tiny structures in cells called microtubules stable by using two helpers, JNK and Gsk3β.
Methodology
The study used differentiated neuroblastoma cells to analyze the effects of Wnt signaling on microtubule stability through JNK and Gsk3β.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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