HIV-Associated TB in An Giang Province, Vietnam: Epidemiology and Treatment Outcomes
Author Information
Author(s): Thuy Trinh Thanh, Shah N. Sarita, Anh Mai Hoang, Nghia Do Trong, Thom Duong, Linh Truong, Sy Dinh Ngoc, Duong Bui Duc, Chau Luu Thi Minh, Mai Phung Thi Phuong, Wells Charles D., Laserson Kayla F., Varma Jay K.
Primary Institution: U.S. Centers for Disease Control and Prevention
Hypothesis
What are the factors associated with treatment outcomes for HIV-infected TB patients in An Giang, Vietnam?
Conclusion
HIV-associated TB in An Giang, Vietnam, is linked to poor treatment outcomes, but those taking co-trimoxazole (CTX) had significantly better results.
Supporting Evidence
- 26% of HIV-infected TB patients died during treatment.
- 79% of the patients were male.
- 83% of patients had smear-positive TB.
- Patients taking CTX had a 70% lower rate of unsuccessful outcomes compared to those not taking it.
Takeaway
This study found that many people with HIV and TB in Vietnam are not doing well, but taking a specific medicine called CTX can help them get better.
Methodology
The study retrospectively analyzed data from HIV-infected TB patients diagnosed in An Giang from 2001 to 2004, using WHO definitions for treatment outcomes and conducting multivariate analysis to identify risk factors.
Potential Biases
Potential bias due to reliance on clinical records without independent verification.
Limitations
The study was retrospective and relied on existing clinical records, which may not accurately reflect CTX use or other unmeasured factors affecting mortality.
Participant Demographics
Of the 637 patients, 79% were male, 51% were aged 25-34 years, and 35% reported sex with commercial sex workers as their HIV risk factor.
Statistical Information
P-Value
0.4
Confidence Interval
0.3–0.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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