Key Risk Factors, Sex Differences, and the Influence of High-Intensity Exercise on Colorectal Carcinogenesis: A 10-Year Cohort Study Based on 1,120,377 Individuals from the NHISS Data
2024

Key Risk Factors and Exercise Impact on Colorectal Cancer

Sample size: 1120377 publication 10 minutes Evidence: high

Author Information

Author(s): Jee Hyunseok

Primary Institution: School of Kinesiology, Yeungnam University

Hypothesis

This study aims to examine data from the National Health Insurance Sharing Service (NHISS) to investigate factors influencing colon cancer incidence.

Conclusion

High-intensity exercise (3 days/week) reduced colorectal cancer risk by 26%, and optimal threshold points for GGT and CCI were identified as 23.50 U/L and 1.50, respectively.

Supporting Evidence

  • High-intensity exercise reduced colorectal cancer risk by 26%.
  • Optimal threshold points for GGT and CCI were established.
  • Significant differences in health metrics were observed between CRC and non-CRC groups.

Takeaway

Doing intense exercise a few times a week can help lower the chances of getting colon cancer.

Methodology

This retrospective cohort study analyzed data from the NHISS database over 10 years, using logistic regression and receiver operating characteristic curve assessments.

Potential Biases

Residual confounding cannot be entirely ruled out.

Limitations

Potential biases from propensity score matching and unmeasured confounders may influence results.

Participant Demographics

The study included 1,120,377 individuals aged 1–85 years, with a matched control group based on sex, age, and region.

Statistical Information

P-Value

0.023

Confidence Interval

0.569–0.958

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.3390/curroncol31120553

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