DroID: The Drosophila Interactions Database
Author Information
Author(s): Yu Jingkai, Pacifico Svetlana, Liu Guozhen, Finley Russell L Jr
Primary Institution: Wayne State University School of Medicine
Hypothesis
DroID aims to provide a comprehensive resource for annotated gene and protein interactions specifically for Drosophila melanogaster.
Conclusion
DroID is the most comprehensive interactions database available for Drosophila, providing freely accessible data that can be searched and analyzed.
Supporting Evidence
- DroID includes 131,659 links among 9,511 D. melanogaster genes.
- 22.3% of interactions in DroID received a confidence score above 0.5.
- Interactions with higher confidence scores are more likely to be biologically relevant.
Takeaway
DroID is like a big library that helps scientists find out how genes and proteins in fruit flies work together.
Methodology
DroID combines various gene and protein interaction data, annotates them with confidence scores, and provides user-friendly interfaces for searching and analyzing the data.
Potential Biases
The confidence scoring system may be influenced by the training datasets used, which could introduce bias.
Limitations
No single dataset adequately covers all available data, and the presence of false positive interactions can limit the value of interaction datasets.
Participant Demographics
The database focuses on Drosophila melanogaster genes and interactions.
Statistical Information
P-Value
<2.2*10-16
Statistical Significance
p<2.2*10-16
Digital Object Identifier (DOI)
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