ZMIZ1 Enhances Androgen Receptor Activity with Short Polyglutamine Tracts
Author Information
Author(s): Li Xiaomeng, Zhu Chunfang, Tu William H., Yang Nanyang, Qin Hui, Sun Zijie
Primary Institution: Stanford University School of Medicine
Hypothesis
ZMIZ1 enhances the transcriptional activity of the androgen receptor (AR) with different lengths of polyglutamine tracts in prostate cancer cells.
Conclusion
ZMIZ1 preferentially enhances the activity of androgen receptors with shorter polyglutamine tracts, which may have implications for prostate cancer progression.
Supporting Evidence
- ZMIZ1 enhances AR-mediated transcription specifically with shorter polyQ tracts.
- Co-expression of ZMIZ1 significantly increased ligand-induced activity of ARQ9 and ARQ24.
- ZMIZ1 interacts more strongly with AR proteins containing shorter polyQ lengths.
Takeaway
ZMIZ1 helps a protein called the androgen receptor work better when it has a shorter part made of repeating units, which is important for prostate cancer.
Methodology
The study used various biochemical and functional approaches, including transfection assays, immunoprecipitation, and chromatin immunoprecipitation (ChIP) to assess the interactions and effects of ZMIZ1 on AR activity.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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