High volume-rate 4D echocardiography for imaging of electromechanical activation and cardiac strain
2024

High Volume-Rate Echocardiography for Heart Imaging

Sample size: 16 publication Evidence: moderate

Author Information

Author(s): Grondin Julien, Schleifer Hannah J., Weber Rachel, Lee Changhee, Tourni Melina, Konofagou Elisa E.

Primary Institution: Columbia University

Hypothesis

Can high volume-rate echocardiography simultaneously map cardiac electromechanical activation and strain in a single heartbeat?

Conclusion

The study shows that high-volume rate imaging can noninvasively capture electromechanical activation and systolic strains of the heart in a single heartbeat.

Supporting Evidence

  • The mean electromechanical activation time was 72.6±15.2 ms in the atria and 132.4±19.7 ms in the ventricles.
  • Volumetric right and left atrial strains were consistent across all volunteers, with a mean end-systolic global longitudinal strain of 26.8±6.5% in the atria.
  • Ventricular global longitudinal strain was found to be -16.6±3.4% across all volunteers.

Takeaway

This study found a way to take pictures of the heart that show how it works electrically and mechanically all at once, which can help doctors understand heart problems better.

Methodology

The study used a 32x32 ultrasound matrix array connected to four synchronized ultrasound scanners to perform high volume-rate imaging in 16 young volunteers.

Potential Biases

Manual selection of electromechanical activation times may introduce operator bias.

Limitations

Four volunteers were excluded due to suboptimal echocardiographic windows, and the study was limited to healthy young individuals.

Participant Demographics

16 young volunteers, average age 28.1 years, 6 females and 9 males.

Statistical Information

Confidence Interval

95% CI for AGLS: [23.3%, 30.2%]; 95% CI for VGLS: [-18.3%, -14.8%]

Digital Object Identifier (DOI)

10.1371/journal.pone.0313410

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