Helicobacter pylori infection and psoriasis
Author Information
Author(s): Yan Yijiao, Deng Wenhui, Shi Chengzhi, Xie Jiaxin, Sui Daoshun
Primary Institution: The First Clinical Medical School of Guangzhou University of Chinese Medicine
Hypothesis
This study aimed to determine the relationship between H. pylori infection and psoriasis through a systematic review and meta-analysis.
Conclusion
The study found a significant relationship between psoriasis and H. pylori infection, influenced by geography, testing methods, and disease severity.
Supporting Evidence
- The odds ratio for H. pylori infection was significantly higher in the psoriasis group than in the control group.
- The prevalence of H. pylori infection was 50.3% in the psoriasis group and 36.8% in the control group.
- Subgroup analysis revealed no significant differences in H. pylori infection rates between Asia and Europe.
- Patients with moderate-to-severe psoriasis had a significantly higher rate of H. pylori infection than those with mild psoriasis.
Takeaway
This study shows that people with psoriasis are more likely to have a stomach infection called H. pylori, which might make their skin condition worse.
Methodology
The study conducted a systematic review and meta-analysis of articles published in various databases, analyzing data from 15 studies.
Potential Biases
Potential bias due to the limited number of databases and the exclusion of certain studies.
Limitations
The study included literature from only four databases, which may limit its applicability, and some studies had small sample sizes.
Participant Demographics
The study included 2,427 individuals, with varying demographics across the included studies.
Statistical Information
P-Value
<0.0001
Confidence Interval
1.40–2.68
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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