A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51 Reduces Depression
Author Information
Author(s): O'Leary John C. III, Dharia Sheetal, Blair Laura J., Brady Sarah, Johnson Amelia G., Peters Melinda, Cheung-Flynn Joyce, Cox Marc B., de Erausquin Gabriel, Weeber Edwin J., Jinwal Umesh K., Dickey Chad A.
Primary Institution: University of South Florida
Hypothesis
Does the deletion of FKBP5 in aged mice reduce susceptibility to depression?
Conclusion
Ablation of FKBP5 in aged mice leads to reduced depressive-like behavior without affecting cognitive functions.
Supporting Evidence
- FKBP5−/− mice showed reduced immobility in forced swim and tail suspension tests.
- Deletion of FKBP5 did not impair cognitive functions in mice.
- Reduced corticosterone levels were observed in FKBP5−/− mice after stress.
Takeaway
Scientists found that removing a specific gene in older mice made them less sad and more resilient to stress, which could help in developing new depression treatments.
Methodology
The study used FKBP5−/− mice to assess behavioral changes in response to stress and depression models.
Limitations
The study primarily focused on aged mice, which may not fully represent younger populations.
Participant Demographics
Aged mice (17-20 months old) were used in the study.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website