Helicobacter pylori and gastroesophageal reflux disease
Author Information
Author(s): Grande Michele, Cadeddu Federica, Villa Massimo, Attinà Grazia Maria, Muzi Marco Gallinella, Nigro Casimiro, Rulli Francesco, Farinon Attilio M
Primary Institution: Department of Surgery, University Hospital Tor Vergata, Rome, Italy
Hypothesis
What is the correlation between Helicobacter pylori infection and gastroesophageal reflux disease (GERD)?
Conclusion
The study found no significant evidence that H. pylori infection plays an important role in the development of GERD and erosive esophagitis.
Supporting Evidence
- The study included 146 patients with daily reflux symptoms for at least one year.
- H. pylori infection was diagnosed in 35 patients (24%).
- There were no significant differences in age, gender, or symptom severity between H. pylori positive and negative patients.
- Hiatal hernia was found in 66.4% of patients.
- Reflux esophagitis was evidenced in 28% of patients.
Takeaway
The study looked at whether a germ called H. pylori causes heartburn and reflux problems, but it found that it doesn't seem to be a big factor.
Methodology
A prospective study was conducted on 146 patients with GERD, evaluating the prevalence of H. pylori infection and comparing various clinical and endoscopic parameters.
Potential Biases
Potential biases may arise from the exclusion criteria and the reliance on self-reported symptoms.
Limitations
The study's findings may not be generalizable due to the specific patient population and the relatively small sample size.
Participant Demographics
The study included 58 males and 88 females with a mean age of 51.5 years.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website