Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors
1995
Thienothiopyransulfonamides as Complexing Agents for Carbonic Anhydrase Inhibitors
publication
Evidence: high
Author Information
Author(s): Claudiu T. Supuran
Primary Institution: University of Florence, Laboratory of Inorganic and Bioinorganic Chemistry
Hypothesis
The metal complexes of sulfonamides behave as very strong inhibitors of carbonic anhydrase.
Conclusion
The new sulfonamide derivatives are among the most potent carbonic anhydrase inhibitors ever reported.
Supporting Evidence
- The new complexes are more potent CA inhibitors than the parent sulfonamides, with IC50 values around 0.1 nM against isozyme CA II.
- The dual mechanism of inhibition involves sulfonamide anions and metal ions.
- The prepared derivatives were characterized by spectroscopic, magnetic, and conductimetric measurements.
- The Cu(II) complexes of both ligands are the most potent inhibitors.
Takeaway
Scientists made new compounds that help stop a specific enzyme in the body, which can help treat certain eye problems.
Methodology
The study involved preparing metal complexes of sulfonamides and testing their ability to inhibit carbonic anhydrase.
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