Enterovirus 71 Infection in Infants and Children in Ho Chi Minh City, Vietnam
Author Information
Author(s): Tran Chau Bich Nguyen, Nguyen Hieu Trong, Phan Ha Thanh Thi, Tran Ngoc Van, Wills Bridget, Farrar Jeremy, Santangelo Joseph D., Simmons Cameron P.
Primary Institution: Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam
Hypothesis
To better understand the prevalence of EV71 infection, we determined EV71 seroprevalence and seroincidence amongst healthy infants and children in Ho Chi Minh City, Viet Nam.
Conclusion
The study found that EV71 infection is common in Vietnamese infants, with many infections being clinically silent or very mild.
Supporting Evidence
- 55% of cord blood samples contained EV71 neutralizing antibodies.
- The EV71 neutralizing antibody seroconversion rate was 5.6% in the first year and 14% in the second year of life.
- In children aged 5–15 years, seroprevalence of EV71 neutralizing antibodies was 84%.
Takeaway
This study looked at how many babies and kids in Vietnam have a virus called EV71, which can make them sick, and found that a lot of them have it without even knowing.
Methodology
The study involved collecting plasma samples from 200 newborns and conducting seroprevalence and seroincidence surveys over two years.
Potential Biases
Potential bias due to the study being conducted primarily in Ho Chi Minh City, which may not represent rural areas.
Limitations
The study's findings may not be generalizable to less urban areas of Vietnam, and the limit of detection for the neutralization assay may have affected the number of positive samples.
Participant Demographics
Infants and children from Ho Chi Minh City, Vietnam.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 133–307
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website