Study of Apoptosis Proteins in Lung Cancer
Author Information
Author(s): Borner M M, Brousset P, Pfanner-Meyer B, Bacchi M, Vonlanthen S, Hotz M A, Altermatt H J, Schlaifer D, Reed J C, Betticher D C
Primary Institution: University of Bern, Bern, Switzerland
Hypothesis
Alterations in the expression of apoptosis regulatory proteins can influence tumor response to treatment in non-small-cell lung cancer.
Conclusion
The study found that the expression of Bcl-2 and p53 proteins is frequently observed in non-small-cell lung cancer and affects patient outcomes.
Supporting Evidence
- Immunostaining for Bcl-2 was present in 31% of cases.
- Immunostaining for Mcl-1 was present in 58% of cases.
- Immunopositivity for Bax was found in 47% of samples.
- Immunopositivity for Bak was found in 58% of samples.
- p53 immunopositivity was detected in 61% of samples.
- Bcl-2 expression negatively influenced relapse-free survival.
- p53-positive tumors were linked to the development of metastases.
Takeaway
This study looked at proteins that help control cell death in lung cancer and found that some of these proteins are linked to how well patients do after treatment.
Methodology
The study examined the expression of apoptosis-regulating proteins using specific antibodies in archival specimens from lung cancer patients.
Participant Demographics
Patients with radically resected non-small-cell lung cancer.
Statistical Information
P-Value
P=0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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