Diazepam's Effectiveness in Stopping Seizures in Children with Malaria
Author Information
Author(s): Ikumi M.L. Mikumi, Muchohi S.N., Ohuma E.O., Kokwaro G.O., Newton C.R.J.C.
Primary Institution: Kenya Medical Research Institute (KEMRI)/Welcome Trust Research Programme
Hypothesis
Does malaria infection affect the efficacy of diazepam in terminating seizures in children?
Conclusion
Diazepam is less effective in stopping seizures in children with falciparum malaria, but malaria was not an independent risk factor for its failure.
Supporting Evidence
- Diazepam stopped seizures in 25% of all patients.
- Seizures were terminated in fewer patients with P. falciparum parasitaemia compared to those without.
- Malaria was the most common underlying condition, occurring in 48% of children.
Takeaway
This study found that diazepam doesn't work as well for kids with malaria when they have seizures, but malaria itself isn't the only reason for this.
Methodology
The study retrospectively evaluated children with acute convulsions at Kilifi District Hospital over a 7-year period, assessing the efficacy of intravenous diazepam.
Potential Biases
Potential bias due to the retrospective nature of the study and reliance on recorded clinical notes.
Limitations
The study was retrospective and may have incomplete data for some patients.
Participant Demographics
Children aged 0–12.9 years, with a significant portion having cerebral malaria.
Statistical Information
P-Value
0.002
Confidence Interval
0.18–0.56
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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