Anti-tumour activity of tachykinin NK1receptor antagonists on human glioma U373 MG xenograft
2000
Anti-tumour activity of tachykinin NK1 receptor antagonists on human glioma
publication
Author Information
Author(s): Palma C, Bigioni M, Irrissuto C, Nardelli F, Maggi C A, Manzini S
Primary Institution: Menarini Ricerche S.p.A.
Hypothesis
The study investigates the anti-tumour effects of tachykinin NK1 receptor antagonists on human glioma U373 MG xenografts.
Conclusion
The study suggests that tachykinin NK1 receptor antagonists can inhibit the growth of malignant gliomas.
Supporting Evidence
- The presence of substance P was observed in glioma cells, indicating its role in tumor progression.
- Tachykinin NK1 receptor antagonists showed significant anti-tumour activity in the xenograft model.
- Exogenous substance P partially reversed the anti-tumour effects of the NK1 receptor antagonists.
Takeaway
This study found that certain drugs can help stop brain tumors from growing by blocking a specific receptor.
Methodology
The study used U373 MG human glioma cells transplanted into nude mice to assess the effects of tachykinin NK1 receptor antagonists.
Digital Object Identifier (DOI)
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