Crystal Structure of a Lidocaine Analogue
Author Information
Author(s): Maimoune Imane, Kariuki Benson M., El Moutaouakil Ala Allah Abderrazzak, Nchioua Intissar, Alsubari Abdulsalam, Mague Joel T., Zarrouk Abdelkader, Ramli Youssef
Primary Institution: Mohammed V University in Rabat
Hypothesis
The study aims to analyze the crystal structure and intermolecular interactions of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide.
Conclusion
The crystal structure reveals specific hydrogen bonding patterns and molecular interactions that contribute to the compound's stability.
Supporting Evidence
- The study presents a detailed analysis of the crystal structure of a lidocaine analogue.
- Hirshfeld surface analysis indicates that H⋯H contacts are the most common intermolecular interactions.
- C—H⋯O hydrogen bonds form chains of molecules in the crystal structure.
- The piperidine moiety is nearly perpendicular to the phenyl ring, affecting molecular interactions.
Takeaway
The researchers looked at how a new version of lidocaine is arranged in crystals and how its molecules interact with each other.
Methodology
The compound was synthesized through an alkylation reaction and analyzed using Hirshfeld surface analysis.
Digital Object Identifier (DOI)
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