Cromoglycate and Nedocromil Enhance Dexamethasone Suppression in Paw Oedema
Author Information
Author(s): Y. Oyanagui
Primary Institution: Fujisawa Pharmaceutical Co.
Hypothesis
Do the anti-allergic drugs cromoglycate and nedocromil enhance the suppression of paw oedema by dexamethasone?
Conclusion
Cromoglycate and nedocromil enhance the suppression of ischaemic and histamine-induced paw oedema by dexamethasone through a common mechanism involving reactive oxygen species.
Supporting Evidence
- Cromoglycate and nedocromil alone were weak in suppressing ischaemic and histamine paw oedema.
- Both drugs significantly increased the suppression by dexamethasone at 3, 6, 8, and 18 hours after administration.
- The enhancement of dexamethasone action by these drugs was impaired by superoxide dismutase and catalase.
Takeaway
Cromoglycate and nedocromil help a medicine called dexamethasone work better to reduce swelling in mice's paws.
Methodology
Male ddY mice were used to test the effects of cromoglycate and nedocromil on paw oedema induced by ischaemia and histamine, with measurements taken at various time points after dexamethasone administration.
Limitations
The study was conducted on mice, which may not fully represent human responses.
Participant Demographics
Mice used in the study were male ddY mice weighing 30-36 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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