Effect of UFT on Lung Cancer Survival
Author Information
Author(s): Tanaka F, Otake Y, Yanagihara K, Yamada T, Miyahara R, Kawano Y, Li M, Inui K, Wada H
Primary Institution: Department of Thoracic Surgery, Faculty of Medicine, Kyoto University
Hypothesis
The efficacy of postoperative administration of UFT may be influenced by the incidence of apoptosis and p53 status in non-small cell lung cancer.
Conclusion
Apoptotic index and p53 status are useful factors to predict the efficacy of postoperative adjuvant therapy using UFT.
Supporting Evidence
- The 5-year survival rate for the UFT group was 79.9%, compared to 69.8% for the Control group.
- For patients with a higher apoptotic index, the UFT group had a 5-year survival rate of 83.3% versus 67.6% for the Control group.
- Patients without p53 aberrant expression had a 5-year survival rate of 95.2% in the UFT group compared to 74.3% in the Control group.
Takeaway
This study looked at how a cancer treatment called UFT works better for some patients based on their tumor's characteristics.
Methodology
Retrospective review of 162 patients with pathologic stage I non-small cell lung cancer, comparing outcomes between those who received UFT and those who did not.
Potential Biases
Potential biases due to the retrospective nature of the study.
Limitations
The study is retrospective and may have biases related to patient selection.
Participant Demographics
Patients with pathologic stage I non-small cell lung cancer.
Statistical Information
P-Value
0.054 for overall survival; 0.039 for higher apoptotic index; 0.022 for p53 status.
Statistical Significance
p=0.039 for higher apoptotic index; p=0.022 for p53 status.
Digital Object Identifier (DOI)
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