Early Acute Kidney Injury and Sepsis: A Multicentre Evaluation
Author Information
Author(s): Bagshaw Sean M, George Carol, Bellomo Rinaldo
Primary Institution: University of Alberta Hospital
Hypothesis
What is the incidence, risk factors, and outcomes associated with early acute kidney injury in sepsis?
Conclusion
Septic AKI is common during the first 24 hours after ICU admission and is associated with higher mortality and longer hospital stays.
Supporting Evidence
- Sepsis accounted for 32.4% of all patients with AKI.
- 42.1% of septic patients had concomitant AKI.
- Septic AKI was associated with higher ICU and hospital mortality across all strata of RIFLE categories.
- Patients with septic AKI had longer durations of stay in both ICU and hospital.
Takeaway
When people get really sick with sepsis, their kidneys can get hurt too, which makes them even sicker and can lead to longer hospital stays.
Methodology
Retrospective analysis of prospectively collected data from 57 ICUs in Australia, including 120,123 patients admitted for more than 24 hours.
Potential Biases
Potential misclassification of patients due to estimation of baseline kidney function.
Limitations
The study only assessed AKI within the first 24 hours of ICU admission, potentially underestimating the true incidence of septic AKI.
Participant Demographics
Mean age 61.7 years, 59% male, 28.6% with co-morbid disease.
Statistical Information
P-Value
p<0.001
Confidence Interval
1.5 to 1.7
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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