Low TOX Expression Predicts Poor Prognosis in Breast Cancer
Author Information
Author(s): Tan Chunlei, Wu Danping, Yang Xiaotian, Zhang Shiyuan, Liu Shuqiang, Yu Boqian, Yu Xiao, Xiu Yuting, Huang Yuanxi
Primary Institution: Harbin Medical University Cancer Hospital
Hypothesis
The study aims to analyze the expression of TOX in breast cancer patients and its association with prognostic significance.
Conclusion
Low expression of TOX is associated with poorer survival outcomes in breast cancer patients.
Supporting Evidence
- Patients with high TOX expression had longer disease-free survival (DFS) and overall survival (OS) compared to those with low expression.
- Multivariate analysis indicated TOX as a potential independent prognostic factor for both DFS and OS.
- Calibration curve analysis showed good predictive accuracy for postoperative survival rates.
Takeaway
If a breast cancer patient has low levels of a protein called TOX, they might not live as long as those with higher levels of this protein.
Methodology
The study involved 313 breast cancer patients, analyzing TOX expression through immunohistochemistry and assessing survival using Kaplan-Meier and Cox regression analyses.
Potential Biases
Potential biases may arise from the retrospective nature of the study and the single-center design.
Limitations
The study is retrospective and conducted at a single center, which may limit the generalizability of the findings.
Participant Demographics
The median age of participants was 51 years, with a range from 25 to 78 years.
Statistical Information
P-Value
0.00065
Confidence Interval
95% CI: 0.248–0.684
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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