Extravasation of leukocytes in comparison to tumor cells
2008
Comparing the Movement of White Blood Cells and Tumor Cells
publication
Evidence: moderate
Author Information
Author(s): Carina Strell, Frank Entschladen
Primary Institution: Institute of Immunology, Witten/Herdecke University
Hypothesis
Tumor cells utilize leukocytes for their extravasation as linkers to the endothelium.
Conclusion
The study highlights significant differences in the extravasation processes of leukocytes and tumor cells, particularly in how they interact with the endothelium.
Supporting Evidence
- Leukocytes and tumor cells both follow similar steps to exit the bloodstream.
- Leukocytes temporarily change the integrity of blood vessel walls, while tumor cells cause irreversible damage.
- Chemokines guide both leukocytes and tumor cells to their destinations.
Takeaway
White blood cells and tumor cells both move from blood to tissue, but they do it differently. Tumor cells can use white blood cells to help them get through the blood vessel walls.
Digital Object Identifier (DOI)
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