Immune Scoring System for Colorectal Cancer Patients
Author Information
Author(s): Manoğlu Berke, Sökmen Selman, Egeli Tufan, Derici Zekai Serhan, Ağalar Cihan, Aksoy Süleyman Özkan, Losi Lorena, Ohnuma Shinobu
Primary Institution: Dokuz Eylul University Faculty of Medicine
Hypothesis
Can the modified Glasgow Prognostic Score (mGPS) and the CRP–albumin ratio (CAR) predict postoperative outcomes in colorectal cancer patients with peritoneal metastasis?
Conclusion
The CAR and mGPS are effective prognostic factors for predicting high-grade complications and overall survival in colorectal cancer patients with peritoneal metastasis.
Supporting Evidence
- Preoperative mGPS and CAR values were significantly higher in patients with high-grade complications.
- CAR was found to be an independent prognostic factor for overall survival.
- The overall survival rates were higher in colon cancer patients compared to rectal cancer patients.
Takeaway
Doctors can use two tests, CAR and mGPS, to help figure out which colorectal cancer patients might have a harder time after surgery.
Methodology
A retrospective analysis of a prospectively maintained database of 258 patients who underwent cytoreductive surgery for peritoneal metastases of colorectal origin.
Potential Biases
The retrospective nature of the study makes it difficult to establish a solid cause-and-effect relationship.
Limitations
The study is retrospective, with some patients excluded due to missing data, and it may have uncontrolled biases.
Participant Demographics
Group A (rectal cancer) had a median age of 57 years, while Group B (colon cancer) had a median age of 58 years, with no significant differences in gender or co-morbidities.
Statistical Information
P-Value
p=0.002
Confidence Interval
95% CI for CAR: 1.770 (1.235, 2.536)
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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