Association of SMARCA2 Gene Polymorphism with Schizophrenia
Author Information
Author(s): Sengupta Sarojini, Xiong Lan, Fathalli Ferid, Benkelfat Chawki, Tabbane Karim, Danics Zoltan, Labelle Alain, Lal Samarthji, Krebs Marie-Odile, Rouleau Guy, Joober Ridha
Primary Institution: McGill University
Hypothesis
Is there an association between the trinucleotide repeat polymorphism within SMARCA2 and schizophrenia?
Conclusion
The study found no association between the trinucleotide repeat polymorphism within SMARCA2 and schizophrenia.
Supporting Evidence
- Family-based analysis showed no significant preferential transmission of alleles to affected offspring.
- Case/control analysis revealed similar allele and genotype distributions between affected cases and unaffected controls.
- Minor under-transmission of the -1 allele was observed but not significant when corrected for multiple testing.
Takeaway
The researchers looked at a gene to see if a specific change in its DNA was linked to schizophrenia, but they found no connection.
Methodology
The study used family-based and case/control analyses to examine the association of the SMARCA2 polymorphism with schizophrenia.
Potential Biases
The study may have biases due to the phenotypic diversity inherent in schizophrenia.
Limitations
The study acknowledges the phenotypic diversity of schizophrenia and suggests the need for larger sample sizes and examination of specific endophenotypes.
Participant Demographics
Participants included individuals diagnosed with schizophrenia or schizoaffective disorder from French Canadian, Tunisian, and other Caucasian populations.
Statistical Information
P-Value
0.034
Statistical Significance
p > 0.05
Digital Object Identifier (DOI)
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