Seroconversion and dynamics of IgG anti-SARS-CoV-2 antibodies during the pandemic: A two-month observation cohort study on the population of Sleman in Indonesia

2025

Study on IgG Antibodies Against SARS-CoV-2 in Sleman, Indonesia

Sample size: 385 publication 10 minutes Evidence: moderate

Author Information

Author(s): Fachiroh Jajah, Lestari Septi Kurnia, Paramita Dewi Kartikawati, Bintoro Bagas Suryo, Dewi Fatwa Sari Tetra, Lazuardi Lutfan, Rusadi Cici Permata, Sagenah Erti Nur, Arguni Eggi

Primary Institution: Universitas Gadjah Mada, Yogyakarta, Indonesia

Hypothesis

This study aims to identify possible factors that correlate with the seroconversion and serodynamics of IgG antibodies against the RBD of SARS-CoV-2.

Conclusion

A high seroprevalence of the IgG antibody against RBD-SARS-CoV-2 in the Sleman population was found to correlate with COVID-19 vaccination and infection, enhancing hybrid immunity.

Supporting Evidence

79.7% of participants were seropositive for IgG antibodies at baseline.
Vaccination was the strongest factor correlated with seropositivity.
Significant differences in demographics and health behaviors were observed between seropositive and seronegative individuals.
Hybrid immunity was suggested as both infection and vaccination contributed to antibody levels.

Takeaway

The study found that getting vaccinated against COVID-19 helps people build antibodies, which protect them from the virus.

Methodology

A longitudinal study was conducted with participants recruited from the Sleman Health and Demographic Surveillance System, followed up at two time points to measure IgG antibody levels.