Is DOTS-Plus a feasible and cost-effective strategy?
2006

Feasibility and Cost-Effectiveness of Treating Multidrug-Resistant Tuberculosis

Sample size: 171 publication Evidence: moderate

Author Information

Author(s): Paul Garner, Marissa Alejandria, Mary Ann Lansang

Primary Institution: Makati Medical Center

Hypothesis

Is DOTS-Plus a feasible and cost-effective strategy for treating MDR-TB?

Conclusion

Treating MDR-TB patients is feasible and cost-effective in low- and middle-income countries.

Supporting Evidence

  • 61 percent of the 117 analyzed patients were cured.
  • The study combined local cost data with indirect outcome data from other countries.
  • The DOTS-Plus project is supported by the Global Fund to Fight AIDS, Tuberculosis and Malaria.

Takeaway

This study shows that treating people with a tough kind of tuberculosis can be done well and doesn't have to cost a lot of money.

Methodology

A cohort study analyzing treatment outcomes and cost-effectiveness of the DOTS-Plus project in the Philippines.

Potential Biases

Involvement of WHO and Tropical Disease Foundation staff may introduce bias in the evaluation.

Limitations

The study is not an independent evaluation and was conducted under ideal conditions, which may not reflect usual service provision.

Participant Demographics

Patients with multidrug-resistant tuberculosis in the Philippines.

Digital Object Identifier (DOI)

10.1371/journal.pmed.0030350

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