Reducing Cocaine-Seeking Behavior in Rats with Histone Deacetylase Inhibitors
Author Information
Author(s): Romieu Pascal, Deschatrettes Elodie, Host Lionel, Gobaille Serge, Sandner Guy, Zwiller Jean
Primary Institution: CNRS, Strasbourg, France
Hypothesis
Can histone deacetylase inhibitors reduce cocaine-seeking behavior in rats after withdrawal?
Conclusion
The study suggests that HDAC inhibitors can significantly reduce cocaine-seeking behavior in rats, indicating a potential treatment for drug addiction.
Supporting Evidence
- HDAC inhibitors significantly reduced cocaine-seeking behavior in rats.
- Treatment with TsA reduced active hole nose-pokes by 57%.
- PhB treatment resulted in a dose-dependent reduction in cocaine-seeking behavior.
Takeaway
Researchers found that giving special drugs to rats can help them stop wanting cocaine after they have been without it for a while.
Methodology
Male Wistar rats were trained to self-administer cocaine and then treated with HDAC inhibitors before a reinstatement session after a withdrawal period.
Potential Biases
Potential bias in the selection of treatment dosages and the specific animal model used.
Limitations
The study was conducted in a controlled environment with rats, which may not fully represent human addiction.
Participant Demographics
Male Wistar rats, weighing 150–175 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website