Supervised multivariate analysis of sequence groups to identify specificity determining residues
2007
Identifying Key Residues in Protein Families Using Statistical Methods
publication
Evidence: moderate
Author Information
Author(s): Wallace Iain M, Higgins Desmond G
Primary Institution: The Conway Institute of Biomolecular and Biomedical Research, University College Dublin
Hypothesis
Can supervised multivariate analysis effectively identify specificity determining residues in protein families?
Conclusion
The study demonstrates that Between Group Analysis (BGA) is a powerful and flexible method for identifying residues that determine substrate specificity in proteins.
Supporting Evidence
- BGA can analyze any number of functional classes.
- The method is computationally fast and simple.
- BGA was demonstrated on three different protein families.
Takeaway
This study shows a way to find important parts of proteins that help them work with different substances, using a special analysis method.
Methodology
The study used Between Group Analysis (BGA) to analyze multiple sequence alignments of protein families.
Digital Object Identifier (DOI)
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