Factors Affecting Tumor Progression in Lung Cancer
Author Information
Author(s): Shou Y, Hirano T, Gong Y, Kato Y, Yoshida K, Ohira T, Ikeda N, Konaka C, Ebihara Y, Zhao F, Kato H
Primary Institution: Tokyo Medical University
Hypothesis
The study investigates the relationship between angiogenetic factors, matrix metalloproteinases, and tumor progression in non-small-cell lung cancer.
Conclusion
The study found that high levels of VEGF and MMP-2 are associated with poor prognosis in non-small-cell lung cancer patients.
Supporting Evidence
- VEGF expression levels were significantly associated with local invasion and lymph node involvement.
- MMP-2 expression levels were associated with lymphatic permeation.
- Combined overexpression of VEGF and MMP-2 revealed poor prognosis.
Takeaway
This study looked at how certain proteins in lung cancer can affect how the cancer grows and spreads, and found that some of these proteins can predict if a patient will do poorly.
Methodology
The study used immunohistochemical analysis of surgical specimens from 119 non-small-cell lung carcinoma cases.
Statistical Information
P-Value
P = 0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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