PubSort

Pubsort is a free search engine for publications that pre-summarizes each paper’s key findings, hypothesis, conclusion, and supporting evidence.

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Recent Publications

Complete Mitochondrial Genome of Sea Spider Nymphon gracile

Freie Universität Berlin 2006 publication Evidence: moderate

Podsiadlowski Lars, Braband Anke

Title

Complete Mitochondrial Genome of Sea Spider Nymphon gracile

Hypothesis

What is the complete mitochondrial genome sequence of Nymphon gracile and how does it compare to other arthropods?

Conclusion

The mitochondrial genome of Nymphon gracile shows extensive gene rearrangement and suggests a complex evolutionary history.

Targeted Treatment for Low Back Pain

Arthritis Research Campaign National Primary Care Centre, Primary Care Sciences, Keele University, Staffordshire, UK 2008 n=800 publication Evidence: moderate

Elaine M Hay, Kate M Dunn, Jonathan C Hill, Martyn Lewis, Elizabeth E Mason, Kika Konstantinou, Gail Sowden, Simon Somerville, Kanchan Vohora, David Whitehurst, Chris J Main

Title

Targeted Treatment for Low Back Pain

Hypothesis

Is subgrouping using a novel tool combined with targeted treatment better than best current care at reducing long-term disability from low back pain?

Conclusion

The STarT Back Trial aims to determine if a targeted treatment approach for low back pain is more effective than standard care.

Methylation Differences in Head and Neck Cancer

Johns Hopkins Medical Institutions 2011 n=3 publication 10 minutes Evidence: moderate

Hennessey Patrick T., Ochs Michael F., Mydlarz Wojciech W., Hsueh Wayne, Cope Leslie, Yu Wayne, Califano Joseph A.

Title

Methylation Differences in Head and Neck Cancer

Hypothesis

Are tumor-derived xenografts more accurate representations of promoter methylation in primary tumors compared to cancer cell lines?

Conclusion

Tumor-derived xenografts closely resemble primary tumors in promoter methylation patterns, while cancer cell lines show significant differences.

Detecting MicroRNA Precursors Using SAGE

Center for Functional Genomics, Division of Medical Genetics, Department of Medicine, ENH Research Institute 2006 n=29 publication Evidence: moderate

Ge Xijin, Wu Qingfa, Wang San Ming

Title

Detecting MicroRNA Precursors Using SAGE

Hypothesis

Can SAGE technology effectively detect microRNA precursors in human and mouse tissues?

Conclusion

SAGE data indicates the expression of eight human and 14 mouse known miRNA precursors and provides evidence for the existence of two human and seven mouse predicted miRNAs.

Analysis of Glycopeptides from SARS-CoV-2 Spike and ACE2 Proteins

Korea Basic Science Institute 2024 publication Evidence: high

Song Ju Hwan, Jang Sangeun, Choi Jin-Woong, Hwang Seoyoung, Kim Kyoung Heon, Kim Hye-Yeon, Park Sun Cheol, Lee Wonbin, Lee Ju Yeon, Fujimuro Masahiro

Title

Analysis of Glycopeptides from SARS-CoV-2 Spike and ACE2 Proteins

Hypothesis

The glycosylation profiles of the SARS-CoV-2 spike protein and ACE2 receptor influence their interaction and function.

Conclusion

This study provides insights into the glycosylation patterns of SARS-CoV-2 proteins, which may impact vaccine and therapeutic development.

Efficacy and Safety of Anti-TNFα Drugs in Rheumatoid Arthritis

Cruces Hospital, Barakaldo, Spain 2008 n=7087 publication 10 minutes Evidence: moderate

Alonso-Ruiz Alberto, Pijoan Jose Ignacio, Ansuategui Eukene, Urkaregi Arantxa, Calabozo Marcelo, Quintana Antonio

Title

Efficacy and Safety of Anti-TNFα Drugs in Rheumatoid Arthritis

Hypothesis

To analyze available evidence on the efficacy and safety of anti-TNFα drugs for treating rheumatoid arthritis.

Conclusion

Anti-TNFα drugs are effective in RA patients, with similar results irrespective of the drug administered.

Genetic Variants in Complement Factor H and Related Genes Linked to Lupus

University of California Los Angeles 2011 n=15864 publication Evidence: high

Zhao Jian, Wu Hui, Khosravi Melanie, Cui Huijuan, Qian Xiaoxia, Kelly Jennifer A., Kaufman Kenneth M., Langefeld Carl D., Williams Adrienne H., Comeau Mary E., Ziegler Julie T., Marion Miranda C., Adler Adam, Glenn Stuart B., Alarcón-Riquelme Marta E., Pons-Estel Bernardo A., Harley John B., Bae Sang-Cheol, Bang So-Young, Cho Soo-Kyung, Jacob Chaim O., Vyse Timothy J., Niewold Timothy B., Gaffney Patrick M., Moser Kathy L., Kimberly Robert P., Edberg Jeffrey C., Brown Elizabeth E., Alarcon Graciela S., Petri Michelle A., Ramsey-Goldman Rosalind, Vilá Luis M., Reveille John D., James Judith A., Gilkeson Gary S., Kamen Diane L., Freedman Barry I., Anaya Juan-Manuel, Merrill Joan T., Criswell Lindsey A., Scofield R. Hal, Stevens Anne M., Guthridge Joel M., Chang Deh-Ming, Song Yeong Wook, Park Ji Ah, Lee Eun Young, Boackle Susan A., Grossman Jennifer M., Hahn Bevra H., Goodship Timothy H. J., Cantor Rita M., Yu Chack-Yung, Shen Nan, Tsao Betty P.

Title

Genetic Variants in Complement Factor H and Related Genes Linked to Lupus

Hypothesis

Are genetic variants in the CFH and CFHRs region associated with systemic lupus erythematosus (SLE) susceptibility?

Conclusion

The study found that specific genetic variants in the CFH and CFHRs region are associated with an increased risk of developing systemic lupus erythematosus across multiple ethnic groups.

Co-Existent Central and Peripheral Demyelination

Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA 2024 n=1 publication Evidence: low

Narvaez-Caicedo Camila, Jacob Shireen M., Wu Laura, Patel Chilvana

Title

Co-Existent Central and Peripheral Demyelination

Hypothesis

Is there a potential interplay between Hereditary Sensory Motor Neuropathy 1A and Multiple Sclerosis?

Conclusion

This case highlights a rare overlap of peripheral and central demyelination, suggesting potential shared mechanisms between HSMN 1A and MS.

Analysis of Mobile Genetic Elements in Plasmodium Species

University of the Witwatersrand Medical School and National Health Laboratory Service 2006 publication Evidence: moderate

Durand Pierre M, Oelofse Andries J, Coetzer Theresa L

Title

Analysis of Mobile Genetic Elements in Plasmodium Species

Hypothesis

What is the impact of mobile genetic elements on the nucleotide composition of the P. falciparum genome?

Conclusion

Mobile genetic elements vary in frequency among the three Plasmodium species, potentially influencing the AT-rich composition of the P. falciparum genome.

Improved Metabolite Profiling Methods for Chlamydomonas reinhardtii

University of California Davis, Genome Center 2008 n=6 publication 10 minutes Evidence: high

Lee Do Yup, Fiehn Oliver

Title

Improved Metabolite Profiling Methods for Chlamydomonas reinhardtii

Hypothesis

There is a large metabolic difference between the time points of harvest in Chlamydomonas reinhardtii cultures.

Conclusion

The optimized method for metabolite profiling of Chlamydomonas reinhardtii enables rapid analysis of a high number of samples with lower efforts than previous methods.

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