Identifying Genetic Markers for Systemic Sclerosis
2011
n=2296
publication
10 minutes
Evidence: high
Gorlova Olga, Martin Jose-Ezequiel, Rueda Blanca, Koeleman Bobby P. C., Ying Jun, Teruel Maria, Diaz-Gallo Lina-Marcela, Broen Jasper C., Vonk Madelon C., Simeon Carmen P., Alizadeh Behrooz Z., Coenen Marieke J. H., Voskuyl Alexandre E., Schuerwegh Annemie J., van Riel Piet L. C. M., Vanthuyne Marie, van 't Slot Ruben, Italiaander Annet, Ophoff Roel A., Hunzelmann Nicolas, Fonollosa Vicente, Ortego-Centeno Norberto, González-Gay Miguel A., García-Hernández Francisco J., González-Escribano María F., Airo Paolo, van Laar Jacob, Worthington Jane, Hesselstrand Roger, Smith Vanessa, de Keyser Filip, Houssiau Fredric, Chee Meng May, Madhok Rajan, Shiels Paul G., Westhovens Rene, Kreuter Alexander, de Baere Elfride, Witte Torsten, Padyukov Leonid, Nordin Annika, Scorza Raffaella, Lunardi Claudio, Lie Benedicte A., Hoffmann-Vold Anna-Maria, Palm Øyvind, García de la Peña Paloma, Carreira Patricia, Spanish Scleroderma Group, Varga John, Hinchcliff Monique, Lee Annette T., Gourh Pravitt, Amos Christopher I., Wigley Frederick M., Hummers Laura K., Hummers J., Nelson J. Lee, Riemekasten Gabriella, Herrick Ariane, Beretta Lorenzo, Fonseca Carmen, Denton Christopher P., Gregersen Peter K., Agarwal Sandeep, Assassi Shervin, Tan Filemon K., Arnett Frank C., Radstake Timothy R. D. J., Mayes Maureen D., Martin Javier
Title
Identifying Genetic Markers for Systemic Sclerosis
Hypothesis
The study aims to determine the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc).
Conclusion
The study identified three new non-HLA genes associated with systemic sclerosis subphenotypes and highlighted the genetic heterogeneity underlying the disease.