E4F1 and its Role in Brain Development and Pyruvate Metabolism
Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France
2024
n=123
publication
10 minutes
Evidence: high
Di Michele Michela, Attina Aurore, Roux Pierre-François, Tabet Imène, Laguesse Sophie, Florido Javier, Houdeville Morane, Choquet Armelle, Encislai Betty, Arena Giuseppe, De Blasio Carlo, Wendling Olivia, Frenois François-Xavier, Papon Laura, Stuani Lucille, Fuentes Maryse, Jahannault Talignani Céline, Rousseau Mélanie, Guégan Justine, Buscail Yoan, Dupré Pierrick, Michaud Henri-Alexandre, Rodier Geneviève, Bellvert Floriant, Kulyk Hanna, Ferraro Peyret Carole, Mathieu Hugo, Close Pierre, Rapino Francesca, Chaveroux Cédric, Pirot Nelly, Rubio Lucie, Torro Adeline, Sorg Tania, Ango Fabrice, Hirtz Christophe, Compan Vincent, Lebigot Elise, Legati Andrea, Ghezzi Daniele, Nguyen Laurent, David Alexandre, Sardet Claude, Lacroix Matthieu, Le Cam Laurent
Title
E4F1 and its Role in Brain Development and Pyruvate Metabolism
Hypothesis
E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development.
Conclusion
E4F1 is crucial for maintaining translation fidelity and preventing neuronal cell death during brain development by regulating pyruvate metabolism.